The Role of VDR inside the Intestinal Microbiome

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Our data claim that active 1, 25D signaling enriched Aire+ mTECs and enhanced their colocalization with the transcription factor Vdr. The part overlap regarding the binding sites of the two proteins is definitely consistent with the pleiotropic actions of both molecules and shows that they may have interaction functionally. one particular, 25D increased the expression of Aire mRNA and improved the number of Aire+ cells in thymic pieces, and caused Aire-dependent TRA mRNAs in sorted TEC populations. 1, 25D treatment also enhanced Vdr colocalization with Domaine in mTECs, cTECs, and thymocytes.

We showed that intestinal tract epithelial VDR regulates autophagy through their interaction with all the protein ATG16L1 and that reduced intestinal VDR expression correlates with dysbiosis in a colitis model. Maintenance of the microbe product butyrate increases intestinal tract epithelial VDR expression and restores microbial homeostasis. This can be a first demonstration that VDR impacts the intestinal tract microbiome through its interaction with ATG16L1 and autophagy. We suggest that intestinal epithelial VDR is a crucial regulator of intestinal homeostasis and that modulation of this radio could be an successful therapeutic technique to treat inflammatory bowel disease.